Prevalence of excessive daytime sleepiness among patients with atopic dermatitis

Sleep disorders have received considerable attention from the dermatologic community, especially in patients with atopic dermatitis. We confirmed that excessive daytime sleepiness is a common problem among dermatitis, it affecting 46.1% of evaluated subjects. demonstrated was also significantly associated disease severity dermatitis and had detrimental impact on quality life, well-being burden. These findings suggest importance careful assessment management sleep patients. Intervention programs for this population might help to improve their life well-being. Dear Editor, (AD).1 The prevalence complaints very high adults AD, reportedly ranging 33% 87.1%.2 Excessive major consequence serious consequences both individuals society since can increase ratio motor vehicle accidents, work-related incidents, deaths.3, 4 For example, recent study reported subjects were 2.09 times more likely than without dermatitis.5 Little known about occurs adult objective our assess evaluate clinical factors This an observational, cross-sectional study. approved by local ethics committees at CHU de Grenoble, France (reference number 20.04.18.61210) conducted according principles Declaration Helsinki. Survey participants recruited between January April 2021, sample French polling institute (HC Conseil Paris, France) general above 18 years age using stratified, proportional sampling replacement design. Consecutive considered best nonprobability methods controlling bias because includes all available Respondents who being diagnosed AD physician invited participate study, they included if they're able understand French; provided consent study; aged years. questionnaire constructed endorsed patient members Eczema Association. All answered web-based sociodemographic characteristics subjective evaluations attributable or not Objective assessed Patient-Oriented Measure (POEM).6 POEM self-assessment tool used monitor activity children AD. asks frequency occurrence 7 symptoms during preceding week (itching, sleep, bleeding, weeping, skin cracking, flaking off, dryness). It rated out 28. previously proposed banding scores create three groups: mild (0–7), moderate (8–16), severe (17–28).7 In addition, asked complete 2 generic questionnaires (Short Form-12 (SF-12), Dermatology Quality Life Index (DLQI) -specific burden questionnaire, ABS-A. specifically developed daily life.8 DLQI self-administered measures QOL over past disease. Scores range 0 30, where score equal diminished life.9 SF-12 short version Short Form-36 (SF-36), measure enabling health status population.10 Two scores, Physical Component Summary (PCS-12) Mental (MCS-12), be calculated 12 questions SF-12. There no overall score. A higher indicates better life. questionnaires. Epworth Sleepiness Scale (ESS) contains 8 questions, 24.11 defined ≥10.12 general, greater 10 as sleepiness. WBQ12 reliable valid 4-item subscales: Negative Well-Being (NWB), Energy (ENE), Positive (PWB). Items are 4-point Likert-scale 3 (“all time”) (“not all”).13 validation these used. intensity itch, burn sensation pain visual analog scale (VAS) mean symptom experienced within last days (VAS mean) time examination exam). ranged (no itch/burn sensation/pain) points (worst sensation/pain imaginable). chi-square test Fisher's exact compare differences categorical data, independent t continuous variables. Correlations tested parameters verified Spearman rank correlation test. value lower 0.05 statistically significant. Among 2530 1561 female (61.7%), 969 male (38.3%) (mean ± standard deviation (SD) 42.4 13.9 years). Of patients, 1236 (48.9%; 44.9 14.3 years) 1294 (51.1%; 39.9 13.1 (p < 0.001). (1167/2530), significant difference women (45% 702/1561) men (48% 465/969). However, frequent ≤ 45 ans (796/1573 [50.6%] vs. 371/957 [38.8%] people sleepiness, 58.4% felt tired, exhausted worn time, 50.1% often, 42.1% sometimes 25.1% never. imputability frequently (47.2% 32.9% 0.05)). Patients shorter nighttime duration (6.51 1.53 6.92 1.46 p 0.05) getting less 6 h night least (64.4% 46.2% 0.05). total still exclusively sleep-onset insomnia (SOI), 51.2% maintenance (SMI), 47.4% SOI SMI. presented (61.4% 42.4%, showed 0.05; Table 1). noted R: 0.482, 0.01; Figure Correlation Complaining pruritus, cutaneous To knowledge, has performed most comprehensive evaluation U.S. National Health Interview found eczema likelihood regular sleepiness.14 observed fatigue those Nighttime problems predictors know, optimal requires effective therapy including sensation.15 Our results provide basis future and, perhaps importantly, new avenues interventions aimed improving DA. granted Pfizer. None declare. Bruno Halioua: Methodology (Equal); Writing – original draft (Lead); review & editing (Lead). Jonathan Taieb: Validation (Equal). Julien Seneschal: Conceptualization Florence Corgibet: Laurent Misery: Adrien Marquie: Formal analysis Stéphanie Merhand: Funding acquisition Delphine Staumont-Salle: Khaled Ezzedine: Charles Investigation Marie-Aleth Richard: data support corresponding author upon reasonable request.